Endocrine Abstracts

There is compelling evidence that shiftworkers are at risk of developing metabolic disturbances, diabetes and obesity as a result of disruption to circadian rhythms, but the mechanisms by which this may occur are not clear. The Bmal1 null mouse, which lacks both central and peripheral tissue rhythms, was used in this study to address the role of circadian rhythmicity in metabolic homeostasis.Male Bmal1 null mice and wild-type litter mates (2 month...